Article
MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset.
Oral oncology - 1 Jun 2009
Hamid Sharifah, Yang Yi-Hsin, Peng Karen Ng Lee, Ismail Siti Mazlipah, Zain Rosnah Binti, Lim Kue Peng, Wan Mustafa Wan Mahadzir, Abraham Mannil Thomas, Teo Soo-Hwang, Cheong Sok Ching
Abstract excerpt
The MDM2 SNP309 has been associated with increased expression of the protein which could suppress p53 function, and has been shown to modulate risk to cancer. We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. We...
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