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Article

Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma.

Molecular carcinogenesis - 1 Feb 2011

Sousa Hugo, Pando Mafalda, Breda Eduardo, Catarino Raquel, Medeiros Rui

Abstract excerpt

Recent studies refer that amplification/overexpression of the principal negative regulator of p53 (Mdm2) is frequently found in several malignancies. Several studies have associated a polymorphism (SNP309 T/G) in the promoter region of MDM2 with higher levels of this protein, which will favor p53...

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Source

Identifiers

PMID: 21229604
DOI: 10.1002/mc.20689

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21229604-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma.PMID 21229604Read ↗

Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma.Semantic proximity Read ↗

MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset.Semantic proximity Read ↗

MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population.Semantic proximity Read ↗

Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.Semantic proximity Read ↗

Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.Semantic proximity Read ↗

Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population.Semantic proximity Read ↗

The MDM2 309 T/G polymorphism is associated with head and neck cancer risk especially in nasopharyngeal cancer: a meta-analysis.Semantic proximity Read ↗

No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil.Semantic proximity Read ↗

Mdm2 SNP309 G-variant is associated with invasive growth of human urinary bladder cancer.Semantic proximity Read ↗

Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

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