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Article

Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma.

Acta oto-laryngologica - 1 Jul 2008

Nakashima Masashi, Kondo Satoru, Shimizu Yoshinori, Wakisaka Naohiro, Murono Shigeyuki, Furukawa Mitsuru, Yoshizaki Tomokazu

Abstract excerpt

CONCLUSIONS: The GG genotype of MDM2 SNP309 is associated with an earlier onset of head and neck squamous cell carcinoma (HNSCC) in the Japanese population. SNP309 may be a key factor in the tumorigenesis of HNSCC as well as other hereditary or sporadic tumors. OBJECTIVE: This study was designed to evaluate the association between the single nucleotide polymorphism (SNP) 309 in the MDM2 gene with HNSCC. An MDM2...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 18568525
DOI: 10.1080/00016480701724904

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma.PMID 18568525Read ↗

Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

MDM2 309T>G polymorphism and risk of squamous cell carcinomas of head and neck: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset.Semantic proximity Read ↗

Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma.Semantic proximity Read ↗

Impact of MDM2 single nucleotide polymorphism on oral squamous cell carcinoma risk.Semantic proximity Read ↗

Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.Semantic proximity Read ↗

MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.Semantic proximity Read ↗

Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma.Semantic proximity Read ↗

The MDM2 309 T/G polymorphism is associated with head and neck cancer risk especially in nasopharyngeal cancer: a meta-analysis.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.Semantic proximity Read ↗

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