Article
Localization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein 1.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Pontzer C H, Ott T L, Bazer F W, Johnson H M
Abstract excerpt
Ovine trophoblast protein 1 (oTP-1) is the interferon alpha (IFN-alpha) variant with potent antiviral activity and low toxicity that is responsible for maternal recognition of pregnancy in sheep. To examine the structure/function basis for the potent antiviral activity of oTP-1, we have exploited...
Topics
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Binding Sites
- Cell Line
- Cell Membrane
- Circular Dichroism
- Endometrium
- Female
- Genetic Variation
- Immune Sera
- Interferon Type I
- Molecular Sequence Data
- Peptides
- Pregnancy
- Pregnancy Proteins
- Protein Conformation
- Sheep