Article
Localization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein 1.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Pontzer C H, Ott T L, Bazer F W, Johnson H M
Abstract excerpt
Ovine trophoblast protein 1 (oTP-1) is the interferon alpha (IFN-alpha) variant with potent antiviral activity and low toxicity that is responsible for maternal recognition of pregnancy in sheep. To examine the structure/function basis for the potent antiviral activity of oTP-1, we have exploited the direct approach of synthetic peptide competition with oTP-1 for receptor, using N-terminal oTP-1-(1-37) and...
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