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Pregnancy and Interferon Tau Regulate Major Histocompatibility Complex Class I and β2-Microglobulin Expression in the Ovine Uterus1

1 May 2003

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules, consisting of an alpha chain and beta2-microglobulin (beta2MG), play an important role in immune rejection responses by discriminating self and nonself and are increased by type I interferons during antiviral responses. Interferon tau (IFNtau), the pregnancy-recognition signal in ruminants, is a type I interferon produced by the ovine conceptus between...

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PMID: 12606392
DOI: 10.1095/biolreprod.102.012708

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