Article
A protein with a binding specificity similar to NF-kappa B binds to a steroid-dependent regulatory element in the ovalbumin gene.
The Journal of biological chemistry - 5 Jun 1991
Schweers L A, Sanders M M
Abstract excerpt
The chicken ovalbumin gene is regulated at the level of transcription by four classes of steroid hormones. A steroid-dependent regulatory element (SDRE) found from -900 to -732 is required for this steroid-mediated induction. To define more precisely sequences of the SDRE required for steroidal induction, a series of exonuclease III deletions were made in the 3' end of the SDRE. Fusion genes containing the mutant...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chickens
- Chloramphenicol O-Acetyltransferase
- Cycloheximide
- DNA Fingerprinting
- Electrophoresis, Polyacrylamide Gel
- Female
- Interferon Type I
- Methylation