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The expression of SPARC in human tumors is consistent with its role during cell competition

1 Mar 2011

Abstract excerpt

In Drosophila, the elimination of viable but suboptimal cells is mediated by cell competition, ensuring that these cells do not accumulate during development. In addition, certain genes such as the Drosophila homologue of human c-myc (dmyc) are able to transform cells into supercompetitors, which eliminate neighboring wild-type cells by apoptosis and overproliferate leaving total cell numbers unchanged. We have...

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PMID: 21655431
DOI: 10.4161/cib.4.2.14232

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