Article
Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2).
International immunology - 1 Jun 1997
Godkin A, Friede T, Davenport M, Stevanovic S, Willis A, Jewell D, Hill A, Rammensee H G
Abstract excerpt
HLA-DQ8 (A1*0301, B1*0302) and -DQ2 (A1*0501, B1*0201) are both associated with diseases such as insulin-dependent diabetes mellitus and coeliac disease. We used the technique of pool sequencing to look at the requirements of peptides binding to HLA-DQ8, and combined these data with naturally seq...
Topics
- Alleles
- Amino Acid Sequence
- B-Lymphocytes
- Cell Line, Transformed
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- HLA-DQ Antigens
- Herpesvirus 4, Human
- Humans
- Ligands
- Molecular Sequence Data
- Peptides
- Protein Binding