Article
FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.
Experimental cell research - 15 Jul 2010
Hafner Christian, Di Martino Erica, Pitt Eva, Stempfl Thomas, Tomlinson Darren, Hartmann Arndt, Landthaler Michael, Knowles Margaret, Vogt Thomas
Abstract excerpt
FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo. The functional consequences of these mutations in human skin are as yet unknown. In this study we analyzed the functional effects of the most common FGFR3 mutation in benign skin tumors, the R248C FGFR3 hotspot mutation, in human HaCaT keratinocytes. The cells...
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