Article
Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein.
The New England journal of medicine - 9 Nov 1995
Polvikoski T, Sulkava R, Haltia M, Kainulainen K, Vuorio A, Verkkoniemi A, Niinistö L, Halonen P, Kontula K
Abstract excerpt
BACKGROUND: The epsilon 4 allele of apolipoprotein E has been associated with an increased risk of late-onset Alzheimer's disease. In a cohort of elderly subjects we prospectively investigated the relation between the apolipoprotein E genotype, dementia, and the accumulation of beta-amyloid prote...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Cerebral Cortex
- Cohort Studies
- DNA
- Dementia
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Neurofibrillary Tangles
- Prospective Studies