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Article

Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia.

Oncogene - 1 Apr 2023

Wang Dandan, Zheng Lichuan, Cheng Bowie Yik Ling, Sin Chun-Fung, Li Runsheng, Tsui Sze Pui, Yi Xinyu, Ma Alvin Chun Hang, He Bai Liang, Leung Anskar Yu Hung, Sun Xuan

Abstract excerpt

Isocitrate dehydrogenase 2 (IDH2) mutations occur in more than 15% of cytogenetically normal acute myeloid leukemia (CN-AML) but comparative studies of their roles in leukemogenesis have been scarce. We generated zebrafish models of IDH2R172K and IDH2R140Q AML and reported their pathologic, functional and transcriptomic features and therapeutic responses to target therapies. Transgenic embryos co-expressing...

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Identifiers

PMID: 36739363
DOI: 10.1038/s41388-023-02611-y
PMCID: PMC10101851

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