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Article

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.

British journal of haematology - 1 Oct 2011

Forrester A Michael, Grabher Clemens, McBride Eileen R, Boyd Ellen R, Vigerstad Märta H, Edgar Alexander, Kai Fui-Boon, Da'as Sahar I, Payne Elspeth, Look A Thomas, Berman Jason N

Abstract excerpt

NUP98-HOXA9 [t(7;11) (p15;p15)] is associated with inferior prognosis in de novo and treatment-related acute myeloid leukaemia (AML) and contributes to blast crisis in chronic myeloid leukaemia (CML). We have engineered an inducible transgenic zebrafish harbouring human NUP98-HOXA9 under the zebrafish spi1(pu.1) promoter. NUP98-HOXA9 perturbed zebrafish embryonic haematopoiesis, with upregulated spi1 expression...

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Share to GATA1 Transcription Factor
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Leukemia, Experimental

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Source

Identifiers

PMID: 21810091
DOI: 10.1111/j.1365-2141.2011.08810.x

Genes

HOXA9
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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