Article
A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Ma Alvin C H, Shi Xiangguo, He Bai-Liang, Guo Yuhan, Leung Anskar Y H
Abstract excerpt
The recent advent of next-generation sequencing (NGS) has greatly accelerated identification of gene mutations in myeloid malignancies at unprecedented speed that will soon outpace their functional validation by conventional laboratory techniques and animal models. A high-throughput whole-organism model is useful for the functional validation of new mutations. We recently reported the use of zebrafish to evaluate...
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