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Article

Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function.

Journal of cell science - 1 Jul 2011

Sinha Sutapa, Mondal Gourish, Hwang Eun Ju, Han Da Woon, Dutta Shamit K, Iyer Seethalakshmi, Karumanchi S Ananth, Kim Keun Il, Couch Fergus J, Mukhopadhyay Debabrata

Abstract excerpt

One of the mechanisms of tumorigenesis is that the failure of cell division results in genetically unstable, multinucleated cells. Here we show that pVHL, a tumor suppressor protein that has been implicated in the pathogenesis of renal cell carcinoma (RCC), plays an important role in regulation of cytokinesis. We found that pVHL-deficient RCC 786-O cells were multinucleated and polyploid. Reintroduction of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21652636
DOI: 10.1242/jcs.087122
PMCID: PMC3113667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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