Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.

doi:10.1128/MCB.19.2.1486

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Article

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.

Molecular and cellular biology - 1 Feb 1999

Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis G N, Klausner R D

Abstract excerpt

Mutation of the von Hippel-Lindau tumor suppressor gene (vhl) causes the von Hippel-Lindau cancer syndrome as well as sporadic renal clear cell carcinoma. To pursue our study of the intracellular localization of VHL protein in relation to its function, we fused VHL to the green fluorescent protei...

Topics

Animals
Base Sequence
Biological Transport, Active
COS Cells
Carcinoma, Renal Cell
Cell Fusion
Cell Nucleus
Cytoplasm
DNA Primers
Dactinomycin
Genes, Tumor Suppressor
Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Kidney Neoplasms

Ligases

Luminescent Proteins

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9891082
DOI: 10.1128/MCB.19.2.1486
PMCID: PMC116077

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9891082-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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