Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier

Abstract excerpt

<h4>Background</h4> A principal protective component of the mammalian blood-brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1 ) and ABCG2 (encoded by ABCG2 ) on the lumenal surface of endothelial cells. The zebrafish P-gp homolog Abcb4 is expressed at the BBB and phenocopies human P-gp. Comparatively little is known about the four zebrafish ho...

Topics

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• ATP-Binding Cassette Transporters
• Drug Resistance, Multiple
• Drug Resistance, Neoplasm
• Drug Transport and Resistance Mechanisms
• Gene Expression Regulation
• Neoplasms
• Pharmacological Effects and Toxicity Studies
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

083c0f3b-6f16-5ebd-826f-bf890e4e3912

DOI

10.1101/2023.05.18.539313