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Article

ABCG2 – a transporter for all seasons

8 May 2004

Abstract excerpt

The human ABCG2 (ABCP/MXR/BCRP) protein is a recently recognized ABC half-transporter, which forms homodimers in the plasma membrane and actively extrudes a wide variety of chemically unrelated compounds from the cells. This protein protects our cells and tissues against various xenobiotics, with a crucial role in the intestine, liver, placenta, and the blood-brain barrier. Moreover, ABCG2 seems to have a key...

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PMID: 15165903
DOI: 10.1016/j.febslet.2004.03.123

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