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Article

Multidrug Resistance and Cancer: The Role of the Human ABC Transporter ABCG2

1 Oct 2002

Abstract excerpt

A variety of human cancers become resistant or are intrinsically resistant to treatment with conventional chemotherapy, a phenomenon called multidrug resistance. This broad-based resistance results in large part, but not solely, from overexpression of members of the ATP-binding cassette (ABC) superfamily of membrane transporters, including P-glycoprotein, various members of the multidrug resistance associated...

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PMID: 12369998
DOI: 10.2174/1389203023380521

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