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Article

Energetic landscape of polycystin channel gating.

EMBO reports - 5 Jul 2023

Ng Leo Ct, Harris Brandon J, Larmore Megan, Ta My C, Vien Thuy N, Tokars Valerie L, Yarov-Yarovoy Vladimir, DeCaen Paul G

Abstract excerpt

Members of the polycystin family (PKD2 and PKD2L1) of transient receptor potential (TRP) channels conduct Ca2+ and depolarizing monovalent cations. Variants in PKD2 cause autosomal dominant polycystic kidney disease (ADPKD) in humans, whereas loss of PKD2L1 expression causes seizure susceptibility in mice. Understanding structural and functional regulation of these channels will provide the basis for interpreting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37158562
DOI: 10.15252/embr.202356783
PMCID: PMC10328073

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