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Article

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

The Journal of biological chemistry - 17 Oct 2008

Feng Shuang, Okenka Genevieve M, Bai Chang-Xi, Streets Andrew J, Newby Linda J, DeChant Brett T, Tsiokas Leonidas, Obara Tomoko, Ong Albert C M

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2 protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP) superfamily and functions as a non-selective calcium channel. PC2 has been found to form oligomers in native tissues suggesting that it may form...

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Source

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Identifiers

PMID: 18701462
DOI: 10.1074/jbc.M803834200
PMCID: PMC2568912

Genes

PKD2
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.PMID 18701462Read ↗

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