Article

A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models

2021-06-02

Abstract excerpt

We aimed to investigate a potentially sexually dimorphic role of Calcitonin Gene-Related Peptide (CGRP) in mouse and rat models of pain. Based on findings in migraine where CGRP has a preferential pain-promoting effect in female rodents, we hypothesized that CGRP antagonists and antibodies would attenuate pain sensitization more efficaciously in female than male mice and rats. In hyperalgesic priming induced by ac...

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Literature Corpus work: 5c0c19c6-d9df-5c51-9611-98c90237de0c
DOI: 10.1101/2021.06.02.446716

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