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Article

Novel CYP2C9 and VKORC1 gene variants associated with warfarin dosage variability in the South African black population.

Pharmacogenomics - 1 Jul 2011

Mitchell Cathrine, Gregersen Nerine, Krause Amanda

Abstract excerpt

AIM: Warfarin is a widely used therapeutic agent for long-term oral anticoagulation worldwide. Its administration is challenging owing to its narrow therapeutic range and serious adverse effects. Several environmental factors and numerous genes, of which CYP2C9 and VKORC1 are the most important, have been associated with interindividual dosage variability. Many studies have been conducted to understand warfarin...

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Source

Identifiers

PMID: 21635147
DOI: 10.2217/pgs.11.36

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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