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Article

Evaluation of the effects of VKORC1 polymorphisms and haplotypes, CYP2C9 genotypes, and clinical factors on warfarin response in Sudanese patients.

European journal of clinical pharmacology - 1 Nov 2011

Shrif Nassr Eldin M A, Won Hong-Hee, Lee Seung-Tae, Park Jun-Hee, Kim Ka-Kyung, Kim Min-Ji, Kim Seonwoo, Lee Soo-Youn, Ki Chang-Seok, Osman Ihsan M, Rhman Enaam A, Ali Ibtisam A, Idris M N A, Kim Jong-Won

Abstract excerpt

OBJECTIVE: African populations, including the Sudanese, are underrepresented in warfarin pharmacogenetic studies. We designed a study to determine the associations between the polymorphisms and haplotype structures of CYP2C9 and VKORC1 and warfarin dose response in Sudanese patients, one of the most genetically diverse populations in Africa. MATERIAL AND METHODS: The effect of the CYP2C9 polymorphisms (*2, *3,...

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Source

Identifiers

PMID: 21590310
DOI: 10.1007/s00228-011-1060-1

Genes

VKORC1

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Evaluation of the effects of VKORC1 polymorphisms and haplotypes, CYP2C9 genotypes, and clinical factors on warfarin response in Sudanese patients.PMID 21590310Read ↗

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