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Article

Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011

Won Angela P, Garbarino Joan E, Lim Wendell A

Abstract excerpt

The yeast Saccharomyces cerevisae has four distinct mitogen-activated protein kinase kinases (MAPKKs), each of which has a distinct functional identity characterized by communication with specific upstream and downstream partners to form distinct functional pathways. These four kinases belong to one family, sharing closely related catalytic domains. How have these four related kinases diverged to take on four...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21628578
DOI: 10.1073/pnas.1016337108
PMCID: PMC3116413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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