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Article

Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms.

Science (New York, N.Y.) - 14 Feb 2003

Park Sang-Hyun, Zarrinpar Ali, Lim Wendell A

Abstract excerpt

How scaffold proteins control information flow in signaling pathways is poorly understood: Do they simply tether components, or do they precisely orient and activate them? We found that the yeast mitogen-activated protein (MAP) kinase scaffold Ste5 is tolerant to major stereochemical perturbations; heterologous protein interactions could functionally replace native kinase recruitment interactions, indicating that...

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Identifiers

PMID: 12511654
DOI: 10.1126/science.1076979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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