Article
Distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae.
The Journal of biological chemistry - 9 Dec 2011
Palacios Lorena, Dickinson Robin J, Sacristán-Reviriego Almudena, Didmon Mark P, Marín María José, Martín Humberto, Keyse Stephen M, Molina María
Abstract excerpt
MAPK phosphatases (MKPs) are negative regulators of signaling pathways with distinct MAPK substrate specificities. For example, the yeast dual specificity phosphatase Msg5 dephosphorylates the Fus3 and Slt2 MAPKs operating in the mating and cell wall integrity pathways, respectively. Like other M...
Topics
- Amino Acid Motifs
- Binding Sites
- DNA
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Proteins
- Phosphorylation
- Protein Binding
- Protein Structure, Tertiary
- Protein Tyrosine Phosphatases
- RNA-Binding Proteins