Article
Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 1996
Yablonski D, Marbach I, Levitzki A
Abstract excerpt
The mitogen-activated protein kinase cascade of the Saccharomyces cerevisiae pheromone response pathway is organized on the Ste5 protein, which binds each of the kinases of the cascade prior to signaling. In this study, a structure-function analysis of Ste5 deletion mutants uncovered new functional domains of the Ste5 protein and revealed that Ste5 dimerizes during the course of normal signal transduction....
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