Article
Infection of CV1 cells expressing the polyoma virus middle T antigen or the SV40 agnogene product with simian virus 40 host-range mutants.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Jun 1990
Spence S L, Tack L C, Wright J H, Carswell S, Pipas J M
Abstract excerpt
SV40 viruses bearing mutations at the carboxy-terminus of large T antigen exhibit a host-range phenotype: such viruses are able to grow in BSC monkey kidney cells at 37 degrees C, but give at least 10,000-fold lower yields than wild type virus in BSC cells at 32 degrees C or in CV1 monkey kidney cells at either temperature. The block to infection in the nonpermissive cell type occurs after the onset of viral DNA...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Capsid
- Cell Line
- Cell Transformation, Viral
- Gene Expression
- Genes, Viral
- Kinetics
- Mutation
- Phenotype
- Phosphorylation