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Article

SV40 large T antigen functions at two distinct steps in virion assembly.

Virology - 1 Oct 1994

Spence S L, Pipas J M

Abstract excerpt

The SV40 large T antigen mutant 5002 has two amino acid substitutions (L19-F; P28-S) and is defective for productive viral infection as demonstrated by its small plaques that arise very late and by a 100-fold reduced yield of infectious progeny. 5002 replicates viral DNA at the same time postinfe...

Topics

Antigens, Polyomavirus Transforming
Capsid
Capsid Proteins
DNA, Viral
Defective Viruses
Models, Biological
Mutation
Myristic Acid
Myristic Acids
Precipitin Tests
Simian virus 40
Virion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8091652
DOI: 10.1006/viro.1994.1524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8091652-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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