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Article

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.

The Journal of experimental medicine - 6 Jun 2011

Rybtsov Stanislav, Sobiesiak Malgorzata, Taoudi Samir, Souilhol Céline, Senserrich Jordi, Liakhovitskaia Anna, Ivanovs Andrejs, Frampton Jon, Zhao Suling, Medvinsky Alexander

Abstract excerpt

The aorta-gonad-mesonephros region plays an important role in hematopoietic stem cell (HSC) development during mouse embryogenesis. The vascular endothelial cadherin⁺ CD45⁺ (VE-cad⁺CD45⁺) population contains the major type of immature pre-HSCs capable of developing into long-term repopulating definitive HSCs. In this study, we developed a new coaggregation culture system, which supports maturation of a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21624936
DOI: 10.1084/jem.20102419
PMCID: PMC3173253

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