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Detailed characterization of the human aorta‐gonad‐mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer

1 Jun 1999

Abstract excerpt

The definitive long-term repopulating human hematopoietic stem cell, which seeds the adult blood system, was previously thought to derive from the extra-embryonic yolk sac. However, there is now considerable evidence that in both avian and murine systems, yolk sac hematopoietic cells are largely a transient, embryonic population and the definitive stem cell, in fact, derives from a distinct region within the...

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PMID: 10373018
DOI: 10.1002/(sici)1097-0177(199906)215:2<139::aid-dvdy6>3.0.co;2-#

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