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Article

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.

Nature - 4 Mar 2010

Boisset Jean-Charles, van Cappellen Wiggert, Andrieu-Soler Charlotte, Galjart Niels, Dzierzak Elaine, Robin Catherine

Abstract excerpt

Haematopoietic stem cells (HSCs), responsible for blood production in the adult mouse, are first detected in the dorsal aorta starting at embryonic day 10.5 (E10.5). Immunohistological analysis of fixed embryo sections has revealed the presence of haematopoietic cell clusters attached to the aortic endothelium where HSCs might localize. The origin of HSCs has long been controversial and several candidates of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20154729
DOI: 10.1038/nature08764

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