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Article

Thyroid hormone receptor β1 domains responsible for the antagonism with the ras oncogene: role of corepressors.

Oncogene - 17 Feb 2011

García-Silva S, Martínez-Iglesias O, Ruiz-Llorente L, Aranda A

Abstract excerpt

The thyroid hormone receptor (TR) is a suppressor of ras-mediated responses. To characterize the receptor domains involved in this function, we analyzed a panel of TRβ1 mutants for their ability to interfere with ras-driven cyclin D1 activation, formation of transformation foci and tumor growth in nude mice. Our results show that the domains and mechanisms responsible for the anti-transforming and...

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Source

Identifiers

PMID: 20956942
DOI: 10.1038/onc.2010.464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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