Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

Abstract excerpt

Richard Lang and colleagues identify a mechanism by which myeloid cells regulate the pattern of blood-vessel branching in the post-natal retina. They show that macrophages inhibit branching by secreting Wnt ligands that use a non-canonical pathway to induce secretion of the VEGF inhibitory receptor Flt1. Myeloid cells are a feature of most tissues. Here we show that during development, retinal myeloid cells...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angiogenesis and VEGF in Cancer
• Share to Apelin-related biomedical research
• Share to Axon Guidance and Neuronal Signaling