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Article

TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2020

Jabłońska Agnieszka, Zagrapan Branislav, Neumayer Christoph, Klinger Markus, Eilenberg Wolf, Nanobachvili Josif, Paradowska Edyta, Brostjan Christine, Huk Ihor

Abstract excerpt

TLRs are a family of signaling sensors that play a crucial role in the host immune response and are involved in the modulation of inflammatory processes. To study their contribution to abdominal aortic aneurysm (AAA) formation and development, we determined the frequency of TLR2, TLR3, TLR4, and TLR9 single-nucleotide polymorphisms (SNPs) and investigated the association between polymorphisms and the risk of AAA...

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PMID: 32284335
DOI: 10.4049/jimmunol.1901014

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