Article
Association between seven single nucleotide polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm.
Journal of vascular surgery - 1 May 2015
Saratzis Athanasios, Bown Matthew J, Wild Ben, Nightingale Peter, Smith Jacqueline, Johnson Christopher, Melas Nikolaos, Kitas George D
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm (AAA) formation involves an inflammatory and proteolytic process. Previous studies suggest that AAA is a multifactorial disease with a strong genetic background. This study evaluated the role of seven important functional single nucleotide polymorphisms (SNPs) in AAA. METHODS: This was a case-control study of two independent populations: 397 AAA patients (mean aortic...
Topics
- Aged
- Alleles
- Aortic Aneurysm, Abdominal
- Case-Control Studies
- Cohort Studies
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Greece
- Humans
- Inflammation
- Male
- Matrix Metalloproteinase 3