Article
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.
Circulation - 29 Jan 2002
Hirotani Shinichi, Otsu Kinya, Nishida Kazuhiko, Higuchi Yoshiharu, Morita Takashi, Nakayama Hiroyuki, Yamaguchi Osamu, Mano Toshiaki, Matsumura Yasushi, Ueno Hikaru, Tada Michihiko, Hori Masatsugu
Abstract excerpt
BACKGROUND: Recently, reactive oxygen species (ROS) have emerged as important molecules in cardiac hypertrophy. However, the ROS-dependent signal transduction mechanism remains to be elucidated. In this study, we examined the role of an ROS-sensitive transcriptional factor, NF-kappaB, and a mitogen-activated protein kinase kinase kinase, apoptosis signal-regulating kinase 1 (ASK1), in G-protein-coupled receptor...
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