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Article

H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways.

Journal of molecular and cellular cardiology - 1 Jun 2003

Kwon Susan H, Pimentel David R, Remondino Andrea, Sawyer Douglas B, Colucci Wilson S

Abstract excerpt

Reactive oxygen species (ROS) can act as signaling molecules to stimulate either hypertrophy or apoptosis in cardiac myocytes. We tested the hypothesis that the phenotypic effects of ROS are due to differential, concentration-dependent activation of specific kinase signaling pathways. Adult rat ventricular myocytes were exposed to H(2)O(2) over a broad concentration range (10-1000 microM). Low concentrations of...

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Identifiers

PMID: 12788379
DOI: 10.1016/s0022-2828(03)00084-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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