Article
Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase.
Scientific reports - 27 Dec 2019
Björck Markus L, Vilhjálmsdóttir Jóhanna, Hartley Andrew M, Meunier Brigitte, Näsvik Öjemyr Linda, Maréchal Amandine, Brzezinski Peter
Abstract excerpt
In cytochrome c oxidase (CytcO) reduction of O2 to water is linked to uptake of eight protons from the negative side of the membrane: four are substrate protons used to form water and four are pumped across the membrane. In bacterial oxidases, the substrate protons are taken up through the K and the D proton pathways, while the pumped protons are transferred through the D pathway. On the basis of studies with...
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