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Article

An active site mutation induces oxygen reactivity in D-arginine dehydrogenase: A case of superoxide diverting protons.

The Journal of biological chemistry - 1 Jun 2024

Quaye Joanna A, Wood Kendall E, Snelgrove Claire, Ouedraogo Daniel, Gadda Giovanni

Abstract excerpt

Enzymes are potent catalysts that increase biochemical reaction rates by several orders of magnitude. Flavoproteins are a class of enzymes whose classification relies on their ability to react with molecular oxygen (O2) during catalysis using ionizable active site residues. Pseudomonas aeruginosa D-arginine dehydrogenase (PaDADH) is a flavoprotein that oxidizes D-arginine for P. aeruginosa survival and biofilm...

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Identifiers

PMID: 38762175
DOI: 10.1016/j.jbc.2024.107381
PMCID: PMC11193025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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