Proton transfer from glutamate 286 determines the transition rates between oxygen intermediates in cytochrome c oxidase.

doi:10.1016/s0005-2728(00)00194-8

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Article

Proton transfer from glutamate 286 determines the transition rates between oxygen intermediates in cytochrome c oxidase.

Biochimica et biophysica acta - 15 Aug 2000

Adelroth P, Karpefors M, Gilderson G, Tomson F L, Gennis R B, Brzezinski P

Abstract excerpt

We have investigated the electron-proton coupling during the peroxy (P(R)) to oxo-ferryl (F) and F to oxidised (O) transitions in cytochrome c oxidase from Rhodobacter sphaeroides. The kinetics of these reactions were investigated in two different mutant enzymes: (1) ED(I-286), in which one of the key residues in the D-pathway, E(I-286), was replaced by an aspartate which has a shorter side chain than that of the...

Topics

Deuterium
Electron Transport
Electron Transport Complex IV
Glutamic Acid
Mutation
Oxidation-Reduction
Oxygen
Photolysis
Protons
Rhodobacter sphaeroides

Source

Open in PubMed

Identifiers

PMID: 11004473
DOI: 10.1016/s0005-2728(00)00194-8

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