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Article

DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans.

Journal of the American Society of Nephrology : JASN - 1 Jun 2011

Cao Yali, Schmitz John L, Yang Jiajin, Hogan Susan L, Bunch Donna, Hu Yichun, Jennette Caroline E, Berg Elisabeth A, Arnett Frank C, Jennette J Charles, Falk Ronald J, Preston Gloria A

Abstract excerpt

Anti-neutrophil cytoplasmic autoantibody (ANCA) disease rarely occurs in African Americans and risk factors for the disease in this population are unknown. Here, we genotyped MHC class II alleles and found that, among African Americans, those with proteinase 3-ANCA (PR3-ANCA) had 73.3-fold higher odds of having HLA-DRB1*15 alleles than community-based controls (OR 73.3; 95% CI 9.1 to 591). In addition, a...

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Identifiers

PMID: 21617122
DOI: 10.1681/ASN.2010101058
PMCID: PMC3103736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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