Molecular analysis of HLA class II genes in Goodpasture's disease.

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Article

Molecular analysis of HLA class II genes in Goodpasture's disease.

QJM : monthly journal of the Association of Physicians - 1 Feb 1995

Burns A P, Fisher M, Li P, Pusey C D, Rees A J

Abstract excerpt

A molecular analysis of HLA class II genes was undertaken in order to characterize the previously reported association between HLA-DR2 and glomerulonephritis caused by antibodies to glomerular basement membrane (Goodpasture's disease). Genomic DNA was prepared from 53 patients with Goodpasture's disease and analysed by: (i) Southern blotting using cDNA probes to DRB, DQA and DQB genes, after digestion with TaqI...

Topics

Alleles
Amino Acid Sequence
Anti-Glomerular Basement Membrane Disease
Base Sequence
Blotting, Southern
Disease Susceptibility
Genes, MHC Class II
HLA-DR Antigens
HLA-DR Serological Subtypes
HLA-DR4 Antigen
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Oligonucleotide Probes

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 7704568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7704568-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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