Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.

doi:10.1038/ki.1997.27

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Article

Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.

Kidney international - 1 Jan 1997

Fisher M, Pusey C D, Vaughan R W, Rees A J

Abstract excerpt

Anti-glomerular basement membrane (anti-GBM) disease is caused by autoimmunity to a component of glomerular basement membrane. The major autoantigen has been identified as the NC1 domain of the alpha 3 chain of type IV collagen, and patients are characterized by the presence of specific autoantibodies to this molecule. In common with other autoimmune disorders, there is a strong association with HLA genes, with...

Topics

Alleles
Amino Acid Sequence
Basement Membrane
Binding Sites
Gene Frequency
Genes, MHC Class II
Glomerulonephritis
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Humans
Kidney Glomerulus
Peptides
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8995737
DOI: 10.1038/ki.1997.27

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