Article
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.
Kidney international - 1 Jan 1997
Fisher M, Pusey C D, Vaughan R W, Rees A J
Abstract excerpt
Anti-glomerular basement membrane (anti-GBM) disease is caused by autoimmunity to a component of glomerular basement membrane. The major autoantigen has been identified as the NC1 domain of the alpha 3 chain of type IV collagen, and patients are characterized by the presence of specific autoantibodies to this molecule. In common with other autoimmune disorders, there is a strong association with HLA genes, with...
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