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Mechanism of adenylate kinase. Are the essential lysines essential?

Biochemistry - 8 May 1990

Tian G C, Yan H G, Jiang R T, Kishi F, Nakazawa A, Tsai M D

Abstract excerpt

Using site-specific mutagenesis, we have probed the structural and functional roles of lysine-21 and lysine-27 of adenylate kinase (AK) from chicken muscle expressed in Escherichia coli. The two residues were chosen since according to the nuclear magnetic resonance (NMR) model [Mildvan, A. S., & Fry, D. C. (1987) Adv. Enzymol. 58, 241-313], they are located near the alpha- and the gamma-phosphates, respectively,...

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PMID: 2161682
DOI: 10.1021/bi00470a006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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