Mechanism of adenylate kinase. Are the essential lysines essential?

doi:10.1021/bi00470a006

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Article

Mechanism of adenylate kinase. Are the essential lysines essential?

Biochemistry - 8 May 1990

Tian G C, Yan H G, Jiang R T, Kishi F, Nakazawa A, Tsai M D

Abstract excerpt

Using site-specific mutagenesis, we have probed the structural and functional roles of lysine-21 and lysine-27 of adenylate kinase (AK) from chicken muscle expressed in Escherichia coli. The two residues were chosen since according to the nuclear magnetic resonance (NMR) model [Mildvan, A. S., &...

Topics

Adenylate Kinase
Amino Acid Sequence
Animals
Base Sequence
Calorimetry
Chickens
Cloning, Molecular
Escherichia coli
Kinetics
Lysine
Magnetic Resonance Spectroscopy
Mathematics
Models, Molecular
Models, Theoretical
Molecular Sequence Data
Muscles
Mutation
Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 2161682
DOI: 10.1021/bi00470a006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2161682-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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