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Article

How does activation loop phosphorylation modulate catalytic activity in the cAMP-dependent protein kinase: a theoretical study.

Protein science : a publication of the Protein Society - 1 Apr 2006

Cheng Yuhui, Zhang Yingkai, McCammon J Andrew

Abstract excerpt

Phosphorylation mediates the function of many proteins and enzymes. In the catalytic subunit of cAMP-dependent protein kinase, phosphorylation of Thr 197 in the activation loop strongly influences its catalytic activity. In order to provide theoretical understanding about this important regulatory process, classical molecular dynamics simulations and ab initio QM/MM calculations have been carried out on the...

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PMID: 16522793
DOI: 10.1110/ps.051852306
PMCID: PMC2242471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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