Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of adenylate kinase. The "essential lysine" helps to orient the phosphates and the active site residues to proper conformations.

Biochemistry - 14 Mar 1995

Byeon L, Shi Z, Tsai M D

Abstract excerpt

Although how Lys21 interacts with the substrate MgATP of muscle adenylate kinase (AK) can now be deduced from the crystal structure of Escherichia coli AK.MgAP5A [P1,P5-bis(5'-adenosyl) pentaphosphate] [Müller, C. W., & Schulz, G. E. (1992) J. Mol. Biol. 224, 159-177], its contribution to catalysis has not yet been demonstrated by functional studies since the proton NMR of the K21M mutant was shown to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 7880812
DOI: 10.1021/bi00010a006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of adenylate kinase. The "essential lysine" helps to orient the phosphates and the active site residues to proper conformations.PMID 7880812Read ↗

Mechanism of adenylate kinase. Are the essential lysines essential?Semantic proximity Read ↗

In vitro mutagenesis studies at the arginine residues of adenylate kinase. A revised binding site for AMP in the X-ray-deduced model.Semantic proximity Read ↗

Essential lysine residues in the N-terminal and the C-terminal domain of human adenylate kinase interact with adenine nucleotides as found by site-directed random mutagenesis.Semantic proximity Read ↗

Impacts of mutations on dynamic allostery of adenylate kinase.Semantic proximity Read ↗

Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli.Semantic proximity Read ↗

Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state.Semantic proximity Read ↗

Mechanisms of ATP to cAMP Conversion Catalyzed by the Mammalian Adenylyl Cyclase: A Role of Magnesium Coordination Shells and Proton Wires.Semantic proximity Read ↗

The anatomy of a kinase and the control of phosphate transfer.Semantic proximity Read ↗

A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase.Semantic proximity Read ↗

Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.Semantic proximity Read ↗

Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism.Semantic proximity Read ↗

alpha-Aspartate 261 is a key residue in noncatalytic sites of Escherichia coli F1-ATPase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.