Article
Mechanism of adenylate kinase. The "essential lysine" helps to orient the phosphates and the active site residues to proper conformations.
Biochemistry - 14 Mar 1995
Byeon L, Shi Z, Tsai M D
Abstract excerpt
Although how Lys21 interacts with the substrate MgATP of muscle adenylate kinase (AK) can now be deduced from the crystal structure of Escherichia coli AK.MgAP5A [P1,P5-bis(5'-adenosyl) pentaphosphate] [Müller, C. W., & Schulz, G. E. (1992) J. Mol. Biol. 224, 159-177], its contribution to catalys...
Topics
- Adenosine Triphosphate
- Adenylate Kinase
- Animals
- Base Sequence
- Binding Sites
- Chickens
- Cloning, Molecular
- DNA
- Dinucleoside Phosphates
- Escherichia coli
- Kinetics
- Lysine
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Phosphates
- Protein Conformation