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Article

Diallyl disulfide induces Ca2+ mobilization in human colon cancer cell line SW480.

Archives of toxicology - 1 Feb 2012

Chen Chung-Yi, Huang Chien-Fu, Tseng Ya-Ting, Kuo Soong-Yu

Abstract excerpt

Diallyl disulfide (DADS), one of the major organosulfur compounds of garlic, is recognized as a group of potential chemopreventive compounds. In this study, we examines the early signaling effects of DADS on human colorectal cancer cells SW480 loaded with Ca(2+)-sensitive dye fura-2. It was found that DADS caused an immediate and sustained rise of [Ca(2+)](i) in a concentration-dependent manner (EC(50) = 232 μM)....

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Source

Identifiers

PMID: 21879349
DOI: 10.1007/s00204-011-0748-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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