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Article

Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders.

Biochimica et biophysica acta - 1 Jan 2000

Lebiedzinska Magdalena, Karkucinska-Wieckowska Agnieszka, Giorgi Carlotta, Karczmarewicz Elzbieta, Pronicka Ewa, Pinton Paolo, Duszynski Jerzy, Pronicki Maciej, Wieckowski Mariusz R

Abstract excerpt

p66Shc, the growth factor adaptor protein, can have a substantial impact on mitochondrial metabolism through regulation of cellular response to oxidative stress. We investigated relationships between the extent of p66Shc phosphorylation at Ser36, mitochondrial dysfunctions and an antioxidant defense reactions in fibroblasts derived from five patients with various mitochondrial disorders (two with mitochondrial...

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Source

Identifiers

PMID: 20226758
DOI: 10.1016/j.bbabio.2010.03.005

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders.PMID 20226758Read ↗

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