Article
Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.
The Journal of biological chemistry - 12 Jun 2009
Husain Mohammad, Meggs Leonard G, Vashistha Himanshu, Simoes Sonia, Griffiths Kevin O, Kumar Dileep, Mikulak Joanna, Mathieson Peter W, Saleem Moin A, Del Valle Luis, Pina-Oviedo Sergio, Wang Jin Ying, Seshan Surya V, Malhotra Ashwani, Reiss Krzysztof, Singhal Pravin C
Abstract excerpt
Glomerular visceral epithelial cells (podocytes) play a critical role in the pathogenesis of human immunodeficiency virus (HIV)-associated nephropathy. A key question concerns the mechanism(s) by which the HIV-1 genome alters the phenotype of the highly specialized, terminally differentiated podocytes. Here, using an in vitro system of conditionally immortalized differentiated human podocytes (CIDHPs), we...
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